SUBSTANCE IDENTIFICATION 1.1. Cellulose microcrystalline for column chromatography. . : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . MATERIAL SAFETY DATA SHEET. By producing Avicel . It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . }o]X4]. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Avicel PC 611 (FMC Biopolymer) Supplied by. Revision No. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. : 160182. ( An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 9,LL!z Avicel Microcrystalline Cellulose Physical Properties. Micro Crystalline Cellulose. endobj /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Explore how we work and why we apply science and creativity for a better world to everything we do. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . The aqueous solution to barrier membrane coating. Created Date: 2/10/2020 8:51:41 PM . Chemical Formula: (C6H10O5)n 1.4. 0.25 - 0.37. The figure below illustrates the structural organisation of cellulose within plants. stream Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). /Resources 2 0 R Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? gac74 [#B6`Wnw7 Have an order or account question, find answers in our Online Support articles. CAS 9004-34-6, pH 5 - 7.5. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. In 1964 FMC, Corporation . % It is also inert and biocompatible. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Biologicals by FMC. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. POLYOX resins are nonionic polyethylene oxide solubility polymers. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? << In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. endobj The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. : 160182 Date Approved: 05/25/2010 Revision No. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. l~5C Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Remove JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. HMo@9, U Q!R/1*;` Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Avicel PH-101. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . } !1AQa"q2#BR$3br Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Quick Links. Avicel Microcrystalline Cellulose: Chemical Identifiers. Microcrystalline Cellulose. /Type/Page As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! >> MSDS Ref. It . w !1AQaq"2B #3Rbr Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Wu, K. Zuurman, H.W. stream They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. endobj Request media, explore upcoming events and read our latest updates. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Product and Company Identification . Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Packaging: 34 x 50 kgs fiber drums. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. CAS 9004-34-6. ( Date Approved: 05/25/2010. % In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Microcrystalline Cellulose Side Effects. Fiber supplements can lessen the absorption of some . They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. (1962). : 51395-75-6 Date Approved: 01/31/2008 Revision No. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Product Name: Microcrystalline Cellulose E460 1.2. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Performing this action will revert the following features to their default settings: Hooray! J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Product Name Cellulose microcrystalline. Instead, they obtained a stable colloidal suspension. endobj ChemicalBook. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. };khd5x=fr % They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. *r_ *?~4$ &0Y# <> This Microcrystalline Cellulose . Magazine: Material safety data sheet - FMC Corporation. Are you sure you want to delete your template? %PDF-1.5 Molecular weight: Not Applicable 1.5. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Earth Supplied Products LLC. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Microcrystalline Cellulose / Avicel PH-102. <> Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Regulatory Information LOT #: Available upon request. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Van Veen, G.K. Bolhuis, Y.S. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. stream AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . EMCOCEL 90 M. 130. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe G2W4de=u183KGH{ vQ#4:1\wc II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Medium size standard MCC grade, suited for the majority of directly compressible actives. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Delivering efficient and robust formulations. endobj Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. SDS. endstream Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Well-recognized product that can do it all. /Parent 3 0 R It works as a moisture sponge and permits the controlled growth of spheroids. Origin(s): Plant/Botanical. 2021 Annual Report. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. %PDF-1.4 Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? << Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Home. No. 5 0 obj For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Document(s): certificate data msds. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. We respect your privacy FMC Privacy Policy. (Microcrystalline Cellulose Market Pr. EMCOCEL XLM 90. Explore how you can develop your career and bring your creative ideas to life at IFF. 2008-2023 ChemPoint. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. If you are already a ChemPoint customer then sign up for access to our online ordering website. Material safety data sheet - FMC Corporation. . Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Page 1 of 8. 4. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" q9;v80 MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. . It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. X\o^ Synergies to simplify formulation challenges and reduce operational costs. Battista, O. Alginates also function as actives in some anti-reflux products. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. No. PDF (28.38 mb) 2022 Corporate Fact Sheet. xv}O2' H~KEe9>G/,:9\i Cellulose microcrystalline. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. CoA. Avicel PC 611 Microcrystalline Cellulose. 1 0 obj Microcrystalline Cellulose (MCC) Manufacturing Industry. CAS #: 9004-34-6 1.6. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. <> (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Microcrystalline cellulose is a commonly used excipient in the . Safety Data Sheet for Cellulose microcrystalline 102331. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. 2 0 obj In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Superior Performance: Provides excellent water uptake and rapid swelling . 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, PDF (2.77 mb) 2021 FMC Sustainability Report. Have an order or account question? Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Are you looking for information about products and services by region? Looking for FMC'searnings news? Avicel RC-591 & CL-611 - Description. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. We know that our customers need to provide reliable and consistent products to their patients. >> endobj PharmaCentral 2021 . The most. 0.25 - 0.37. Trademarks: Avicel PH-102. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. It is hygroscopic and insoluble in water. . Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose.