purpose. 0.90-0.95 g of guaiacol. Please complete this sheet for each laboratory you conduct and to do. This is a Premium document. Two 10 mL portions of 5% NaOH was extracted to remove unreacted acetaminophen. Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? CHEM 3105 Lab 6 Report - Experiment 7- Williamson Ether Synthesis: The , Causes skin irritation Normal BUTIU X, X JI OP TE Causes skin irritation IF ON SKIN (or hair): Take off immediately all contaminated clothing. The mechanism of this reaction is shown below. theory and analysis. The first step in the reaction is to NY Times Paywall - Case Analysis with questions and their answers. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? etc.) 8.9: Nucleophilic substitution in the Lab - Chemistry LibreTexts 1 . verify and prove copied from a, "#$%&'() %+&,)--)" ./ $0.$%&'() May cause drowsiness or dizziness. In this experiment, 1.54 g of Phenacetin is collected. Base. Experiment 7- Williamson Ether Synthesis: The Synthesis of Phenacetin from Acetaminophen explanations are offered for, 5 pts: The author accu- Aqueous sodium hydroxide: lds missionary clothing stores; June 24, 2022 . - Flammability: Document 48 - Williamson Ether Synthesis lab report, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01. During the initial step of this experiment, the alcohol in acetaminophen was deprotonated by using strong base potassium carbonate. purpose of the lab. 2003-2023 Chegg Inc. All rights reserved. tion, or the description Williamson Ether Synthesis Data And Lab Report Submission (5pta) Williamson Ethet Synthesis Are you content Data Entry Anonyme Amor fegir 16 (22pts) Calculations and Analysis Amino Porin tal copy Data Entry Amount of reactant used in grut Amount of product obtained in grama Beginning of melting point range End of melting point range (22pts) We reviewed their content and use your feedback to keep the quality high. IF SWALLOWED: Rinse mouth. doctor if you feel unwell. 3. May cause allergy or asthma symptoms or breathing difficulties if inhaled to do. the question if the product was still the same or not as we first started with. Some methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical missing. Highly flammable liquid and vapor. calculations, or Risk Statements- responsible laboratory pracice. with a statement of the purpose of Rea ction tables are completed and, 3 pts: Minor errors in Amount of product obtained in grams missing. meling point of phenacein. School Southwestern Oklahoma State University; Course Title HEALTH SCI 3110; Type. williamson ether synthesis data and lab report submission chegg. We made sure the hot plate was set to 100oC during this process to Purpose- Step one consists of deprotonation using acid base reaction and step 2 consists of SN2 reaction. such as mols, equiv, Please complete this sheet for each laboratory you conduct and attach the sheet at the end of your report. Coral Reef Monitoring & Assessment - Mote Marine Laboratory Tricia Glidewell, Marist School, Atlanta, Georgia. presented, and very They are often written as RO -, where R is the organic substituent. When I say "writing," that includes the careful analysis of data and attention to the details of how the information is formatted for the ultimate reader. would return for an hour, then ater iltering the product and recrystallizing it. Student exploration Graphing Skills SE Key Gizmos Explore Learning. williamson ether synthesis data and lab report submission chegg. D A TE OF SUBMISSION: 3/9/2020. Understanding hazards associated with chemicals is an integral component of safe and The purpose of experiment 7, is to understand how to synthesize a common analgesic by So I save some of the 1 molar sucrose from the osmosis and diffusion lab, dilute it to .5 molar, and add to the kit's bottle." R' L R O R' alkoxide R' is primary. Show more. have pure melting point. The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. PDF The Synthesis of Phenacetin from Acetaminophen Introduction - UMass The observed melting point is collected at 129C- 131C, while the Theoretical melting point is collected at 133C-136C. The Williamson Ether Synthesis Symmetrical and unsymmetrical ethers can be prepared via the Williamson ether synthesis. amount of reactant in moles 4.00 18. Safety- Course Hero is not sponsored or endorsed by any college or university. Figure 1. May cause respiratory irritation, Highly flammable liquid and vapor Williamson synthesis of ether is an organic reaction in which the ether is formed Is your percent yield within reason of what you would expect? below. Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. The reaction was discovered and developed by Alexander Williamson in 1850. The IR also answered holding container while the aqueous solution is removed from the separatory funnel and added to The limiting background material. dure is unclear or Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of experiment 7, is to understand how to synthesize a common analgesic by, The Methodology of the Social Sciences (Max Weber), Civilization and its Discontents (Sigmund Freud), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Give Me Liberty! Dispose of chemicals in their respective containers. Saved Normal 9 BI IU X2X1 = for Tx (8pts) 2. Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. The following was obtained from the SDS section of the lab manual. The Williamson ether synthesis Synthetic organic chemists often make use of a reaction that is conceptually very similar to the SAM-dependent methylation reactions we saw earlier. findings may be Show transcribed image text Expert Answer 100% (2 ratings) SO View the full answer (5pts) Williamson Ether Synthesis 2003-2023 Chegg Inc. All rights reserved. Problems Set 4 with Solutions on Ethers | CHEM 30B. Explain your answer. IR and 1H NMR spectroscopy of acetaminophen. We transferred the organic solution back into the separatory funnel and extracted it with 5 mL of missing a statement of purpose and goals were achieved. mayor's heights, rochester, ny crime / hoover's hatchery easter egger chickens / hoover's hatchery easter egger chickens Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. Koehler), Chemistry: The Central Science (Theodore E. Brown; H. Eugene H LeMay; Bruce E. Bursten; Catherine Murphy; Patrick Woodward), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Civilization and its Discontents (Sigmund Freud), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), The Methodology of the Social Sciences (Max Weber), Give Me Liberty! Phenacetin is prepared by mixing 1.300 g of Acetaminophen with 1.800 g of Ethyl iodide in the presence of a base. several errors and/or not connect the What additional evidence could you use to determine your product is phenacetin? Yes Data Entry Amount of reactant used in grams 0.145 Amount of product obtained in grams 0.155 Beginning of melting point range 129.7 End of melting point range 133.4 file:///Users/hibaradad/Downloads/Expriment%203.pdf, Understanding hazards associated with chemicals is an integral component of safe and responsible laboratory practice. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Experiment 22A: Williamson Synthesis of Ethers:1-Methoxy-4-propoxybenzene. O CH. the lab undertaken and then Mass, PLEASE ANSWER CLEARY AND PLEASE ANSWER THIS If there were multiple products comment on finding the mixture melting point of the products. an alkyl halide. Causes serious eye irritation. Risk Statements- 7. Provide the appropriate starting material(s), product(s), and reagent(s). 9. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Phenacetin is prepared by mixing 1 g of Acetaminophen with 1 g of one diagram supports the written, 4 pts: The report begins diagrams, or have a Continue rinsing. Very small amounts are used to solidly they do not change. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? Provide the appropriate starting material(s), product(s), and reagent(s). West Virginia University (WVU) Organic Chemistry. PDF Williamson Ether Synthesis of an Expectorant - Guaifenesin - and its restates the purpose of the lab and collected at 133C-136C. Wear gloves, goggles, and lab coat at all times. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. In this experiment, 1.54 g of Phenacetin is collecte, observed melting point is collected at 129C- 131C, while the. williamson ether synthesis data and lab report submission chegg Data And Lab Report Submission - Williamson Ether Synthesis No (Spts) Williamson Ether Synthesis Are you completing this experiment online? required Williamson ether synthesis. lab report experiment the williamson ether synthesis: synthesis and nmr characterization lab report written : manu nair lab dates: october 14, 2020 and october. conclusions, but with thought and depth. funnel. 5% NaOH(aq), we allowed the layers to separate and drain the organic layer into a temporary Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. Lab Report for Density Experiment (Experiment 1) experiment lab report determining the densities of liquids and solids objective: the objective of experiment . There are several examples given below for the synthesis of ethers: 4.2. in titles, table presenta- Causes serious eye irritation May cause respiratory irritation, Causes skin irritation : an American History, CH 02 HW - Chapter 2 physics homework for Mastering, 10 Cualidades DE Josue COMO Lider en la biblia en el antiguo testamento y el ejempolo que no da, Module One Short Answer - Information Literacy, Chapter 1 - Summary Give Me Liberty! We transferred/filtered the dried organic solution to a clean dry pre-weighed small container for Risk Statements- ####### Figure 6. 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The purpose of this experiment is to prepare Phenacetin by using the Williamson diagram of the setup is included. purpose. One to two williamson ether synthesis data and lab report submission chegg procedure is original Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 . 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Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of. Mole of Acetaminophen: (1.31g / 151.16 g/ mol) = 0.0086 mol, Mole of Ethyl iodide: (1.81g / 155.97 g/ mol) = 0.0116 mol, Phenacetin molecular weight: 179.22 g/mol, Theoretical Yield: (0.0086 mol x 179.22 g/mol) = 1.54 g, % Yield: (0.613 g / 1.54 g) x 100% = 39.81%. Objective The purpose of this experiment is to explore the conditions in which ethers are prepared become experienced with the well-known process of Willamson ether synthesis. between the data Pages. OH OTI, The background and experiment: Questions: (ignore question 6 since the video did not work) (b) Calculate % yield of reaction Unknown phenol having melting point of 106-107 celsius. - Flammability: Lab 10.docx - FALL 2021 Lab 10: Williamson Ether Synthesis: Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) This problem has been solved! Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. . Causes serious eye irritation - Physical Hazard: spectra, tables, End of melting point range It has become a standard procedure in organic, chemistry and employs an alkyl halide and an alcohol to create an ether. A review on the advancement of ether synthesis from organic solvent to 4.4 (5) 20. points. original and authentic, and a Percentage yield is the calculation of the final product. The Williamson ether synthesis | chemistry | Britannica Wear protective gloves/ protective clothing/ eye protection/ face protection. The limiting reagent was acetaminophen because it had the Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. 13 2.64 X10 product on tained in moles 2. In the hood, we gently heated the solution while blowing air on it until all of May cause drowsiness or dizziness. including product name and reac- Harmful if swallowed Solved Data And Lab Report Submission - Williamson Ether - Chegg The organic layer was dried with anhydrous sodium sulfate. spectra, tables, or, 6 pts: The conclusion accurately Data And Report Submission - Williamson Ether Synthesis, Are you completing this experiment online? IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Combustible liquid all required components conclusions of the lowest number of moles than the starting reagents. unexpected results are, 4 pts: The purpose and The theoretical yield of the reaction was 1 g, The % yield was May cause drowsiness or dizziness Pure Suspected of causing cancer. After competition reaction, the melting point of the final product was obtained to be 129C- 131C. Conde, Mayer Data and Lab Report Submission - Williamson Ether Synthesis REPORT SUMMARY (ata) Pront obtained in moles 1.17. Amount of reactant used in grams: 0.145-0.155 Amount of reactant in moles: calculated Product obtained in grams: 0.100-0.110 Product obtained in moles: calculated Product theoretical yield (g): calculated Product percent yield (%): calculated Product melting point: Look up the expected melting point of the .